Primary progressive aphasia is a clinical syndrome in which patients progressively lose speech and language abilities. Three variants are recognized: logopenic, associated with phonology and/or short-term verbal memory deficits accompanied by left temporo-parietal atrophy; semantic, associated with semantic deficits and anterior temporal lobe atrophy; non-fluent associated with grammar and/or speech-motor deficits and inferior frontal gyrus atrophy. Here, we set out to investigate whether the three variants of PPA can be dissociated based on error patterns in a single language task. We (...) recruited 21 lvPPA, 28 svPPA, and 24 nfvPPA patients, together with 31 healthy controls, and analyzed their performance on an auditory noun-to-verb generation task, which requires auditory analysis of the input, access to and selection of relevant lexical and semantic knowledge, as well as preparation and execution of speech. Task accuracy differed across the three variants and controls, with lvPPA and nfvPPA having the lowest and highest accuracy, respectively. Critically, machine learning analysis of the different error types yielded above-chance classification of patients into their corresponding group. An analysis of the error types revealed clear variant-specific effects: lvPPA patients produced the highest percentage of “not-a-verb” responses and the highest number of semantically related nouns ; in contrast, svPPA patients produced the highest percentage of “unrelated verb” responses and the highest number of light verbs. Taken together, our findings indicate that error patterns in an auditory verb generation task are associated with the breakdown of different neurocognitive mechanisms across PPA variants. Specifically, they corroborate the link between temporo-parietal regions with lexical processing, as well as ATL with semantic processes. These findings illustrate how the analysis of pattern of responses can help PPA phenotyping and heighten diagnostic sensitivity, while providing insights on the neural correlates of different components of language. (shrink)

Single-sided deafness (SSD) or profound unilateral hearing loss obligates the only serviceable ear to capture all acoustic information. This loss of binaural function taxes cognitive resources for accurate listening performance, especially under adverse environments or challenging tasks. We hypothesized that adults with SSD would manifest both functional and structural brain plasticity compared to controls with normal binaural hearing. We evaluated functional alterations using magnetoencephalographic imaging (MEGI) of brain activation during performance of a moderately difficult auditory syllable sequence reproduction task and (...) assessed structural integrity using diffusion tensor magnetic resonance imaging (DTI). MEGI showed the SSD cohort to have increased induced oscillations in the theta band over the left superior temporal cortex and decreased induced gamma band oscillations over the frontal and parietal cortices between 175-475 ms following stimulus onset. DTI showed the SSD cohort to have extensive fractional anisotropy reduction in both auditory and non-auditory tracts and regions. Overlaying functional and structural changes revealed by the two imaging techniques demonstrated close registration of cortical areas and white matter tracts that expressed brain plasticity. Hence, complete loss of input from one ear in adulthood triggers both functional and structural alterations to dorsal temporal and frontal-parietal areas. (shrink)

This study offers a panoramic view of the creative, expository, interpretive, dialectic, polemical, didactic and devotional phases of Dvaita philosophy, and its ...

On the doctrines of Madhva, 13th century exponent of the Dvaita school in Hindu philosophy.

The ideas and conceptions of the Frankfurt philosophical-sociological school, above all the "critical theory of society," the principles of "negative dialectics" and the "great refusal," the utopia of "pacified existence," occupy an important place in the contemporary ideological struggle between the world systems of socialism and capitalism, and comprise a significant ideological and theoretical arsenal of bourgeois ideology and revisionism. And this is not accidental. The "critical theory of society" formulated and argued for by T. Adorno, M. Horkheimer, H. Marcuse, (...) J. Habermas, and others, which proclaims a protest against any social status quo, is used for the critique both of capitalism and actually existing socialism. At the same time it is also interpreted as an imaginary alternative to Marxism, and from, moreover, both right and "left" positions. Therefore the social theory of the Frankfurt school impacts upon the most diverse currents—from bourgeois social thought to the right and "left" varieties of revisionism. The complex evolution made by the representatives of this school in the last half-century contributed to this wide dissemination of the ideas of the Frankfurt school. Theoretical arguments are found in it both by those whose ideology, being directed to the progressive forces, is developed in the direction of Marxism, and by those who fled the soil of Marxism and are hostile to it. (shrink)

Classical treatises on the Advaita and Dvaita school in Hindu philosophy; a study.

On Dvaita philosophy; translated from English.

This article brings together the Aryan Semitic and Sinitic super-cultures in a comparative light in terms of religious numerological leitmotifs. Vedic Hinduism and Zoroastrianism together with the pre-Christian religions of Indo-European Europe belong to this group. Buddhism and to a lesser extent Jainism are also part of this grouping. Judaism and Islam belong to the Semitic group. Daoism and Confucianism come under the Sinitic group. Christianity and Sikhism are hybrid religions that have one leg in the Aryan group and one (...) leg in the Semitic group. The numbers three, six and nine are the hallmarks of Aryan culture the numbers one five and seven are expressed throughout Semitic culture and the numerals three five and eight have received their expression in Chinese culture. (shrink)